Date of Award

Spring 2011

Document Type


Degree Name

Doctor of Philosophy (PhD)


Biomedical Engineering

First Advisor


Second Advisor



Researchers have been trying to fight cancer with synthesis of new bioactive compounds but many of these novel drugs have low solubility in water and it is difficult to deliver them into a patient's body. One way of solving this particular problem is to use nanoscale drug delivery systems. In this dissertation, we describe using an ultrasonic assisted layer-by-layer encapsulation process to prepare anti-cancer drugs with 50∼200 nm particle size with designed coating to achieve sustained release and target delivery.

Two methods for systematic manufacture of low solubility anti-cancer drug nanoparticles were proposed: I) Top-down approach to breakdown larger drug crystals into nano-size particles. 2) Bottom-up approach to fabricate nano size drug crystals from a drug solution.